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Sionna Therapeutics

5.10

-0.1600-3.04%

Post-market: 5.07-0.0300-0.59%19:50 EDT

Volume:1.06M

Turnover:5.40M

Market Cap:229.49M

PE:-2.35

High:5.33

Open:5.26

Low:5.03

Close:5.26

52wk High:54.97

52wk Low:4.01

Shares:45.00M

Float Shares:16.73M

Volume Ratio:0.98

T/O Rate:6.32%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.1683

EPS(LYR):-1.8835

ROE:-32.34%

ROA:-21.54%

PB:0.86

PE(LYR):-2.71

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Overview Company News Filings

RA Capital Management Disposes of Sionna Therapeutics Shares Worth $21.85 Million

These Beaten-Down Stocks Could Bounce Back in January, if History is Any Guide

LifeSci Capital Sticks to Its Hold Rating for Sionna Therapeutics, Inc. (SION)

Analysts’ Opinions Are Mixed on These NA Stocks: HealthStream (HSTM), Inter Parfums (IPAR) and Sionna Therapeutics, Inc. (SION)

Sionna Therapeutics is Maintained at Neutral by Wedbush

Analysts Offer Insights on NA Companies: Jack Henry & Associates (JKHY) and Sionna Therapeutics, Inc. (SION)

Wedbush Raises Price Target on Sionna Therapeutics to $6 From $5, Keeps Neutral Rating

MT Newswires Live

Stifel Nicolaus Keeps Their Hold Rating on Sionna Therapeutics, Inc. (SION)

Sionna Therapeutics Restructures to Focus on Dual Combination

Sionna Therapeutics to Cut 46% of Staff to Focus on Cystic Fibrosis Drug Development

Sionna Therapeutics to reduce workforce by 46%

Sionna Therapeutics, - Board Approves Workforce Reduction of About 46% and Implements Cost-Saving Measures

THOMSON REUTERS

Sionna Therapeutics Announces Plans to Advance Sion-451 + Sion-2222 Dual Combination into Phase 2a Proof-of-Concept Trial

THOMSON REUTERS

Sionna Therapeutics Announces Plans to Advance SION-451 + SION-2222 Dual Combination into Phase 2a Proof-of-Concept Trial

Vertex Has Multiple Portfolio Catalysts With Favorable Risk-Reward, RBC Says

MT Newswires Live

Why Sionna Therapeutics (SION) Is Down 90.9% After Ending SION-719 Add-On To Trikafta Therapy

Simply Wall St.

Sionna Therapeutics price target lowered to $5 from $38 at Freedom Broker

Sionna Therapeutics Cut to Neutral from Buy by BTIG

Sionna Therapeutics, Inc. : Btig Cuts to Neutral from Buy

THOMSON REUTERS

Sionna Therapeutics, Inc. : Jonestrading Cuts to Hold Rating

THOMSON REUTERS

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Hold Rating for Sionna Therapeutics, Inc. 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Maini covers the ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/lifesci-capital-sticks-to-its-hold-rating-for-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/lifesci-capital-sticks-to-its-hold-rating-for-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667009626","title":"Analysts’ Opinions Are Mixed on These NA Stocks: HealthStream (HSTM), Inter Parfums (IPAR) and Sionna Therapeutics, Inc. (SION)","url":"https://stock-news.laohu8.com/highlight/detail?id=2667009626","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667009626?lang=en_us&edition=fundamental","pubTime":"2026-09-16 19:10","pubTimestamp":1789557012,"startTime":"0","endTime":"0","summary":"Analysts have been eager to weigh in on the NA sector with new ratings on HealthStream (HSTM), Inter Parfums (IPAR) and Sionna Therapeutics, Inc. (...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-opinions-are-mixed-on-these-na-stocks-healthstream-hstm-inter-parfums-ipar-and-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-opinions-are-mixed-on-these-na-stocks-healthstream-hstm-inter-parfums-ipar-and-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION","BK4167","NA","HSTM","BK4183","BK4139","IE00B19Z6F94.USD","IPAR","IE0034390439.USD","BK4141"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667864628","title":"Sionna Therapeutics is Maintained at Neutral by Wedbush","url":"https://stock-news.laohu8.com/highlight/detail?id=2667864628","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667864628?lang=en_us&edition=fundamental","pubTime":"2026-09-15 21:46","pubTimestamp":1789479960,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SION/analyst-ratings","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667964110","title":"Analysts Offer Insights on NA Companies: Jack Henry & Associates (JKHY) and Sionna Therapeutics, Inc. (SION)","url":"https://stock-news.laohu8.com/highlight/detail?id=2667964110","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667964110?lang=en_us&edition=fundamental","pubTime":"2026-09-15 19:20","pubTimestamp":1789471229,"startTime":"0","endTime":"0","summary":"Analysts fell to the sidelines weighing in on Jack Henry & Associates (JKHY) and Sionna Therapeutics, Inc. (SION) with neutral ratings, indicating ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-na-companies-jack-henry-associates-jkhy-and-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-na-companies-jack-henry-associates-jkhy-and-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IE00BN0W2V16.EUR","BK4139","JKHY","BK4106","BK4585","SION","IE00BLDYK493.USD","BK4227","IE00BN0W2T93.GBP","BK4588","IE00B64QTZ34.USD","IE00BN0W2W23.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667764914","title":"Wedbush Raises Price Target on Sionna Therapeutics to $6 From $5, Keeps Neutral Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2667764914","media":"MT Newswires Live","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667764914?lang=en_us&edition=fundamental","pubTime":"2026-09-15 18:52","pubTimestamp":1789469550,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics (SION) has an average rating of hold and mean price target of $21.43, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research from majo","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate","earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"express","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667490346","title":"Stifel Nicolaus Keeps Their Hold Rating on Sionna Therapeutics, Inc. (SION)","url":"https://stock-news.laohu8.com/highlight/detail?id=2667490346","media":"TIPRANKS","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667490346?lang=en_us&edition=fundamental","pubTime":"2026-09-15 18:46","pubTimestamp":1789469164,"startTime":"0","endTime":"0","summary":"In a report released today, Paul Matteis from Stifel Nicolaus maintained a Hold rating on Sionna Therapeutics, Inc., with a price target of $7.00. ...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/stifel-nicolaus-keeps-their-hold-rating-on-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate","earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/stifel-nicolaus-keeps-their-hold-rating-on-sionna-therapeutics-inc-sion-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"express","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667695466","title":"Sionna Therapeutics Restructures to Focus on Dual Combination","url":"https://stock-news.laohu8.com/highlight/detail?id=2667695466","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667695466?lang=en_us&edition=fundamental","pubTime":"2026-09-15 04:30","pubTimestamp":1789417820,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics, Inc. ( ($SION) ) has provided an update. On September 9, 2026, Sionna’s board approved a restructuring plan that will cut abou...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/sionna-therapeutics-restructures-to-focus-on-dual-combination?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/sionna-therapeutics-restructures-to-focus-on-dual-combination?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667522695","title":"Sionna Therapeutics to Cut 46% of Staff to Focus on Cystic Fibrosis Drug Development","url":"https://stock-news.laohu8.com/highlight/detail?id=2667522695","media":"Dow Jones","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667522695?lang=en_us&edition=fundamental","pubTime":"2026-09-15 04:28","pubTimestamp":1789417680,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics will cut around 46% of its workforce to focus its resources on developing a cystic fibrosis treatment.The company said Monday that it will advance a combination of SION-451 and SION-2222 to a phase 2a proof-of-concept trial to treat cystic fibrosis. The layoffs and other cost-cutting measures, including discontinuing investments into a separate drug candidate, will provide a cash runway through the second half of 2029, the company said.Sionna said it expects to incur restructuring and other charges of around $6.4 million. The restructuring is expected to be substantially complete by the end of the third quarter, with cash payments continuing through the fourth quarter.The company expects to retain the core capabilities to advance the combination of SION-451 and SION-2222. The phase 2a trial is expected to launch in the first quarter of 2027.Shares fell 4% to $7.93 after-hours on Monday.","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667695395","title":"Sionna Therapeutics to reduce workforce by 46%","url":"https://stock-news.laohu8.com/highlight/detail?id=2667695395","media":"TIPRANKS","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667695395?lang=en_us&edition=fundamental","pubTime":"2026-09-15 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approximate...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-to-reduce-workforce-by-46-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-to-reduce-workforce-by-46-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667693785","title":"Sionna Therapeutics, - Board Approves Workforce Reduction of About 46% and Implements Cost-Saving 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Phase 2a Proof-of-Concept Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2667693215","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667693215?lang=en_us&edition=fundamental","pubTime":"2026-09-15 04:01","pubTimestamp":1789416060,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260914:nTUA90VQWQ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["SION","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667769623","title":"Sionna Therapeutics Announces Plans to Advance SION-451 + SION-2222 Dual Combination into Phase 2a Proof-of-Concept Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2667769623","media":"GlobeNewswire","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667769623?lang=en_us&edition=fundamental","pubTime":"2026-09-15 04:01","pubTimestamp":1789416060,"startTime":"0","endTime":"0","summary":"Post hoc analyses of SION-719 PreciSION CF subset showed a mean placebo-adjusted sweat chloride reduction of up to -8.6 mmol/L consistent with NBD1 biological activity Dual combination Phase 2a trial ","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2026/09/14/3361527/0/en/sionna-therapeutics-announces-plans-to-advance-sion-451-sion-2222-dual-combination-into-phase-2a-proof-of-concept-trial.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BID","BK4588","BK4093","LU0345781412.USD","BK4218","BK4585","BK4139","LU0345780950.USD","SION","BK4181","VEGI","KBWY","PK","CF","LU0630314457.HKD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658290503","title":"Vertex Has Multiple Portfolio Catalysts With Favorable Risk-Reward, RBC Says","url":"https://stock-news.laohu8.com/highlight/detail?id=2658290503","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658290503?lang=en_us&edition=fundamental","pubTime":"2026-08-12 23:02","pubTimestamp":1786546971,"startTime":"0","endTime":"0","summary":"Vertex Pharmaceuticals  has multiple potential catalysts coming from its portfolio that provide a net positive risk-reward profile for the company, RBC Capital Markets said in a Wednesday note.The company is expected to present results from its phase 1 study of VX-828 in patients with cystic fibrosis in H2, with a positive readout potentially strengthening its competitive advantage in the space, RBC analysts said.Favorable data will likely result in modest upside, while unfavorable data will likely lead to little downside, the analysts added.Meanwhile, approval by the US Food and Drug Administration for Vertex's povetacicept in immunoglobulin A nephropathy, with a PDUFA date of Nov. 30, 2026, is likely due to strong interim phase 3 results, the analysts said.They said that the drug's differentiated profile could make it the preferred choice of most doctors.With Sionna Therapeutics  failing to demonstrate significant sweat chloride improvements as an add-on to Trikafta, one of the more ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["IE00B19Z9Z06.USD","LU1778281490.HKD","IDNA","VRTX","IE00B19Z3B42.SGD","IE00BZ9MQY76.HKD","LU1069344957.HKD","LU2362541513.USD","IBBQ","BK4585","LU2362540622.SGD","IE00B2B36J28.USD","BK4588","BK4533","BK4139","LU1674673691.USD","SGXZ57979304.SGD","IE00BJJMRZ35.SGD","TBXU","BIB","LU0061475181.USD","LU0058720904.USD","SION","IE00B19Z9P08.USD","BBH","BK4532","IE00B19Z3581.USD","BK4567","IBB","LU0889565916.HKD","LU1430594728.SGD","IE00BFTCPJ56.SGD","LU2362541273.HKD","LU1559883803.SGD","SG9999013999.USD","VERX","LU0079474960.USD","LU0417517546.SGD","LU2417539215.USD","LU1815336091.USD","LU2237438978.USD","LU2324357040.USD","LU2456880835.USD","LU1093756325.SGD","BK4023","LU0566484027.USD","IE00BJT1NW94.SGD","LU0109394709.USD","GNMX","PBE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658946453","title":"Why Sionna Therapeutics (SION) Is Down 90.9% After Ending SION-719 Add-On To Trikafta Therapy","url":"https://stock-news.laohu8.com/highlight/detail?id=2658946453","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658946453?lang=en_us&edition=fundamental","pubTime":"2026-08-12 04:34","pubTimestamp":1786480479,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics recently reported that its Phase 2a PreciSION CF trial of NBD1 stabilizer SION-719 added to Trikafta did not improve sweat chloride levels, leading the company to discontinue SION-719 as an add-on therapy and to reassess its clinical plans.\nAt the same time, early data from SION-451 combination studies and a cash balance of about US$268.3 million give Sionna room to reconsider how it pursues cystic fibrosis therapies while preserving capital.\nWe’ll now examine 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