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Sionna Therapeutics

5.10

-0.1600-3.04%

Post-market: 5.07-0.0300-0.59%19:50 EDT

Volume:1.06M

Turnover:5.40M

Market Cap:229.49M

PE:-2.35

High:5.33

Open:5.26

Low:5.03

Close:5.26

52wk High:54.97

52wk Low:4.01

Shares:45.00M

Float Shares:16.73M

Volume Ratio:0.98

T/O Rate:6.32%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.1683

EPS(LYR):-1.8835

ROE:-32.34%

ROA:-21.54%

PB:0.86

PE(LYR):-2.71

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Overview Company News Filings

Small U.S. Stocks Decrease; Sionna Therapeutics Posts Biggest Loss

Sionna Therapeutics downgraded to Hold from Buy at JonesResearch

Sionna Therapeutics: Hold Rating Maintained as Disappointing CF Data Drive Price Target Cut from $60 to $6

Sionna Therapeutics downgraded to Neutral from Buy at BTIG

Top Midday Decliners

MT Newswires Live

Sionna Therapeutics downgraded to Neutral from Buy at Guggenheim

Citizens downgrades Sionna Therapeutics as SION-719 miss questions NBD1 thesis

U.S. Stocks on the MOVE-Microsoft, Coastal Financial

Sionna Therapeutics falls -92.0%

Why Sionna Therapeutics Stock is Crashing 92% to a Record Low

Sionna Therapeutics downgraded to Market Perform from Outperform at Citizens

Vertex Stock (VRTX) Soars 7% as Rival Sionna (SION) Crashes 92% on Failed Drug Trial

Top Midday Stories: Intel Offers $15 Billion of Common Stock; Microsoft to Ramp Up Production of Homegrown AI Chip

MT Newswires Live

Sionna Therapeutics downgraded to Market Perform from Strong Buy at Raymond James

Sionna Therapeutics upgraded to Sector Perform from Underperform at RBC Capital

Sionna Therapeutics, Inc. : RBC Raises to Sector Perform from Underperform; Cuts Target Price to $5 from $23

THOMSON REUTERS

Tenax, Sionna Shares Sink After Trial Failures

Wedbush Downgrades Sionna Therapeutics to Neutral From Outperform, Adjusts PT to $5 From $53

MT Newswires Live

Sionna Therapeutics Shares Down 91% After Co's Experimental Drug Misses Mid-Stage Trial Goal

THOMSON REUTERS

Sector Update: Healthcare Stocks Edge Higher Premarket Monday

MT Newswires Live

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U.S. Stocks Decrease; Sionna Therapeutics Posts Biggest Loss","url":"https://stock-news.laohu8.com/highlight/detail?id=2658822951","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658822951?lang=en_us&edition=fundamental","pubTime":"2026-08-11 04:20","pubTimestamp":1786393200,"startTime":"0","endTime":"0","summary":"This article was automatically generated using Dow Jones technology.Shares of small-cap companies dropped Monday, as the Russell 2000 Index declined 0.6%, and the S&P Small Cap 600 Index was down 0.7%.Among companies with a market value of $1 billion to $6.7 billion, Sionna Therapeutics Inc. was the biggest laggard during the session, dropping 91%, followed by shares of Lincoln Educational Services Corp., which dropped 25%. Shares of Bitdeer Technologies Group dropped 20%, CEVA Inc. shares plunged 17%, and AXT Inc. tumbled 17%.Standard Nuclear Inc. was the best performer, surging 36%, followed by AbCellera Biologics Inc., which surged 35%. Obsidian Therapeutics Inc. shares surged 27%, National Energy Services Reunited Corp. surged 23%, and shares of Nutex Health Inc. surged 22%.Major U.S. stock indexes decreased Monday as the Nasdaq Composite Index declined 0.3%. Meanwhile, the S&P 500 Index fell 0.1%, and the Dow Jones Industrial Average declined 0.1%.Data source: Dow Jones Market Dat","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658956120","title":"Sionna Therapeutics downgraded to Hold from Buy at JonesResearch","url":"https://stock-news.laohu8.com/highlight/detail?id=2658956120","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658956120?lang=en_us&edition=fundamental","pubTime":"2026-08-11 03:55","pubTimestamp":1786391743,"startTime":"0","endTime":"0","summary":"JonesResearch downgraded Sionna Therapeutics (SION) to Hold from Buy after SION-719 failed to show meaningful sweat chloride reduction in the Phase...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-downgraded-to-hold-from-buy-at-jonesresearch-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-downgraded-to-hold-from-buy-at-jonesresearch-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658795637","title":"Sionna Therapeutics: Hold Rating Maintained as Disappointing CF Data Drive Price Target Cut from $60 to $6","url":"https://stock-news.laohu8.com/highlight/detail?id=2658795637","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658795637?lang=en_us&edition=fundamental","pubTime":"2026-08-11 03:35","pubTimestamp":1786390519,"startTime":"0","endTime":"0","summary":"In a report released today, Gaurav Maini from LifeSci Capital downgraded Sionna Therapeutics, Inc. to a Hold, with a price target of $6.00. Gaurav ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/ratings/sionna-therapeutics-hold-rating-maintained-as-disappointing-cf-data-drive-price-target-cut-from-60-to-6-ratings-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/ratings/sionna-therapeutics-hold-rating-maintained-as-disappointing-cf-data-drive-price-target-cut-from-60-to-6-ratings-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["PRTO","SION","CF"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658955011","title":"Sionna Therapeutics downgraded to Neutral from Buy at BTIG","url":"https://stock-news.laohu8.com/highlight/detail?id=2658955011","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658955011?lang=en_us&edition=fundamental","pubTime":"2026-08-11 03:20","pubTimestamp":1786389628,"startTime":"0","endTime":"0","summary":"BTIG downgraded Sionna Therapeutics (SION) to Neutral from Buy with no price target after the PreciSION CF trial did not meet its key activity endp...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-downgraded-to-neutral-from-buy-at-btig-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-downgraded-to-neutral-from-buy-at-btig-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658552479","title":"Top Midday Decliners","url":"https://stock-news.laohu8.com/highlight/detail?id=2658552479","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658552479?lang=en_us&edition=fundamental","pubTime":"2026-08-11 03:10","pubTimestamp":1786389002,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics  said Monday it won't advance SION-719 as an add-on therapy to the standard of care, Trikafta, in cystic fibrosis patients after a phase 2a proof-of-concept failed to meet its key activity endpoint of sweat chloride reduction.Shares sank 91%, with intraday trading volume rising to over 32.0 million from a daily average of roughly 493,000.IES  has agreed to acquire DBM Global from Innovate  and other shareholders in a stock-and-cash deal valued at $650 million, Innovate said Monday.Innovate shares plunged 42% as intraday trading volume rising to over 2 million from a daily average of about 326,000.Trade Desk  shares fell after several analysts downgraded the stock, including from DA Davidson, HSBC and BNP Paribas.Shares declined 5%, with intraday trading volume rising to over 38.2 million from a daily average of about 21.5 million.Price: 4.39, Change: -46.66, Percent Change: -91.41","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["TTDU","BK4528","LU2357305700.SGD","LU0348723411.USD","BK4023","BK4129","BK4613","BK4009","BK4585","BK4588","LU1720051017.SGD","BK4548","BK4139","IESC","TTD","VATE","LU1720051108.HKD","SION","LU1548497426.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658953805","title":"Sionna Therapeutics downgraded to Neutral from Buy at Guggenheim","url":"https://stock-news.laohu8.com/highlight/detail?id=2658953805","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658953805?lang=en_us&edition=fundamental","pubTime":"2026-08-11 01:20","pubTimestamp":1786382413,"startTime":"0","endTime":"0","summary":"Guggenheim analyst Yatin Suneja downgraded Sionna Therapeutics (SION) to Neutral from Buy. Published first on TheFly – the ultimate source for real...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-downgraded-to-neutral-from-buy-at-guggenheim-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-downgraded-to-neutral-from-buy-at-guggenheim-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658469958","title":"Citizens downgrades Sionna Therapeutics as SION-719 miss questions NBD1 thesis","url":"https://stock-news.laohu8.com/highlight/detail?id=2658469958","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658469958?lang=en_us&edition=fundamental","pubTime":"2026-08-11 00:55","pubTimestamp":1786380907,"startTime":"0","endTime":"0","summary":"As previously reported, Citizens downgraded Sionna Therapeutics (SION) to Market Perform from Outperform after SION-719 missed in the Phase 2a Prec...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/citizens-downgrades-sionna-therapeutics-as-sion-719-miss-questions-nbd1-thesis-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/citizens-downgrades-sionna-therapeutics-as-sion-719-miss-questions-nbd1-thesis-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658958307","title":"U.S. Stocks on the MOVE-Microsoft, Coastal Financial","url":"https://stock-news.laohu8.com/highlight/detail?id=2658958307","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658958307?lang=en_us&edition=fundamental","pubTime":"2026-08-11 00:33","pubTimestamp":1786379620,"startTime":"0","endTime":"0","summary":"BUZZ-U.S. STOCKS ON THE MOVE-Microsoft, Coastal FinancialAugust 10 (Reuters)-Wall Street's main indexes inched lower on Monday after the S&P 500 and the Dow hit record highs last week, as investors we","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260810:nL6N4470RT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["STDN","ABCL","CECO","BA","VRTX","TENX","APA","SIMO","SPCX","COHR","OXY","AAPL","CVX","NESR","LINT","AIQ","HZO","SCKT","CCB","EVTL","CHMI","SION","AAL","TDIV","SPCH","VRSK","DAL","MSFT","BWMN","SPCF","TH","AIRS","DUK","VATE","AAON","GME","ACHR","RHP","UAL","EBAY","TTD","LITE","VREX","CSQR","JBLU","INTC","NET","NETG","XOM"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658958848","title":"Sionna Therapeutics falls -92.0%","url":"https://stock-news.laohu8.com/highlight/detail?id=2658958848","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658958848?lang=en_us&edition=fundamental","pubTime":"2026-08-11 00:06","pubTimestamp":1786377998,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics (SION) is down -92.0%, or -$46.94 to $4.10. Published first on TheFly – the ultimate source for real-time, market-moving breaki...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-falls-92-0-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-falls-92-0-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658930430","title":"Why Sionna Therapeutics Stock is Crashing 92% to a Record Low","url":"https://stock-news.laohu8.com/highlight/detail?id=2658930430","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658930430?lang=en_us&edition=fundamental","pubTime":"2026-08-11 00:01","pubTimestamp":1786377660,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics is shelving its highly anticipated cystic fibrosis drug candidate, SION-719, after it failed to meet the key endpoint in a proof-of-concept trial.The biotechnology company said Mon","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658439930","title":"Sionna Therapeutics downgraded to Market Perform from Outperform at Citizens","url":"https://stock-news.laohu8.com/highlight/detail?id=2658439930","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658439930?lang=en_us&edition=fundamental","pubTime":"2026-08-10 23:55","pubTimestamp":1786377344,"startTime":"0","endTime":"0","summary":"Citizens downgraded Sionna Therapeutics (SION) to Market Perform from Outperform. 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(VRTX) Soars 7% as Rival Sionna (SION) Crashes 92% on Failed Drug Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2658930455","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658930455?lang=en_us&edition=fundamental","pubTime":"2026-08-10 23:55","pubTimestamp":1786377312,"startTime":"0","endTime":"0","summary":"Shares of American biotech company Vertex Pharmaceuticals ($VRTX) jumped about 7% on Monday after its top rival Sionna Therapeutics ($SION) 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